Persistence paid off. I have TransDEM working under Crossover. I wanted to use Wine, which is the base project to run Windows programs and is free, however Wine is only built to run up to Mac OS 10.14. I'm running Monterey 12.4 beta.
You need to have crossover running. You need to have extra dependancies for TransDEM to run. I don't know what those dependancies are, however Crossover has archives of "bottles" with the extra dependancies already installed, to save time. Download the archives here
https://www.codeweavers.com/support/wiki/mac/mactutorial/unsupported_deps. I did the Win10 64 bit, and then imported the bottle archive. I then installed TransDEM as an unlisted app in the Win10 64bit bottle that came from the archive. As part of the TranDEM install, I installed the extra Microsoft code. I then activated TransDEM by opening up in TransDEM the license file that is on my Mac desktop. Now to call it a night and try things further another time.