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Is TransDEM still an actively supported program? Can it still be purchased?
Yes and yes. It certainly is.
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I sent an email 20 November requesting to purchase a copy of TransDEM Trainz Edition for TRS2019, but have not received any reply.
Apparently that email never made it. Misspelled address?
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I also notice that there seems to be very little recent activity on the English forums and virtually no activity on the German forums.
That has never really been otherwise. TransDEM for Trainz is much more popular outside Germany. You'll find most of the German TransDEM users in the Zusi community, not with Trainz. And TransDEM is a well established program, it probably does not need interactive forum support that often.